Suppression of Phorbol Myristate Acetate-Triggering of Macrophage H2O2Release by Sarcoma 180 Originating Factor
نویسندگان
چکیده
منابع مشابه
Monocyte-associated tissue factor is suppressed by phorbol myristate acetate.
The monocyte is the only normal circulating cell type capable of initiating blood coagulation through the expression of tissue factor. Recently isolated peripheral blood monocytes that contain no demonstrable tissue factor activity can be induced to express tissue factor activity by a number of stimulatory agents. Monocyte-associated tissue factor activity transiently increases in response to a...
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SUMMARY One ,ig of phorbol myristate acetate, an active tumor promoting agent from croton oil, produces a severe, local vascular reaction in skin (ear) of CF1 and STS mice. The response is characterized by hyperemia and edema formation which can be quantitatively monitored by measuring uptake of circulating ‘251-labeled bovine serum albumin. Micro scopic detection of sites of endothelial inju...
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Cultured microvascular endothelial cells isolated from fenestrated capillaries have been shown to express many properties of their in vivo differentiated phenotype, yet they contain very few diaphragmed fenestrae. We show here that treatment of capillary endothelial cells with the tumor promoter, 4 beta-phorbol 12-myristate 13-acetate, induces more than a fivefold increase in the frequency of f...
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The mechanisms involved in coiling phagocytosis are not yet known, and it is not even clear whether this phenomenon is either an incidental event or a specific response. Therefore, the phagocytic uptake of Borrelia burgdorferi and other spirochetes by human monocytes in vitro was used to investigate the involvement of both sides--microbes and phagocytes--in coiling phagocytosis. As seen with el...
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We demonstrate stimulus-dependent incorporation of exogenously added [3H]myristic acid into specific macrophage proteins. In control unstimulated cells an 18-kDa protein is the major acylated species. In cells incubated with bacterial lipopolysaccharide (LPS), or its monoacyl glucosamine phosphate derivative, fatty acid is incorporated into proteins with molecular mass of 68 kDa and a doublet o...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1985
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1985.tb00900.x